Pichia anomala outbreak in a nursery: exogenous source?

摘要: Background. Pichia anomala is a rare cause of fungemia. From February to April, 1998, eight cases fungemia occurred in the intensive care and high risk units Nursery. There were four infants with P. infection, one whom also had Candida parapsilosis two C. infection albicans infection. Objective. To determine factors associated Nursery, especially anomala. Methods. A cohort study 59 newborns. Results. Factors were: central venous catheter (CVC) (P = 0.0006); total parenteral nutrition (TPN) 0.0005); lipid emulsion 0.002); previous antimicrobial use other invasive procedures 0.002). CVC 0.004); TPN 0.018); antibiotic 0.037); 0.037). Evaluation demonstrated that there several technical problems involving administration was manipulated Nursery without precautions. Changes formulation education as adequate technique implemented. During follow-up (1998 1999) only fungemias caused by albicans. Cultures hands personnel negative for Electrophoretic karyotyping showed three profiles. Conclusions. use, nutrition, suggesting acquisition exogenous.