A molecular view of the radioresistance of gliomas
作者： Xuetao Han , Xiaoying Xue , Huandi Zhou , Ge Zhang
DOI: 10.18632/ONCOTARGET.21753
关键词: Stem cell 、 Pathology 、 microRNA 、 Radioresistance 、 Clinical efficacy 、 Primary Brain Tumors 、 Resective surgery 、 Cancer research 、 Radiation therapy 、 Medicine 、 Glioma
摘要: // Xuetao Han 1 , Xiaoying Xue Huandi Zhou and Ge Zhang Department of Radiotherapy, The Second Hospital Hebei Medical University, Shijiazhuang, Hebei, China Correspondence to: Xue, email: xxy0636@163.com Keywords: glioma, radioresistance, signaling pathway, microRNA, glioma stem cells Received: March 08, 2017 Accepted: September 25, Published: October 11, 2017 ABSTRACT Gliomas originate from glial are the most frequent primary brain tumors. High-grade gliomas occur ~4 times more frequently than low-grade gliomas, highly malignant, have extremely poor prognosis. sometimes combined with chemotherapy, is considered treatment choice for used after resective surgery. Despite great technological improvements, radiotherapeutic effect generally limited, due to marked radioresistance exhibited by cells, especially (GSCs). mechanisms underlying this phenomenon multiple remain be fully elucidated. This review attempts summarize current knowledge on molecular basis focusing pathways, microRNAs, hypoxia, microenvironment, GSCs. A thorough understanding complex interactions between molecular, cellular, environmental factors should provide new insight into intrinsic potentially enabling improvement, through novel concurrent therapies, clinical efficacy radiotherapy.
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