RPA3 is a potential marker of prognosis and radioresistance for nasopharyngeal carcinoma

摘要: Radioresistance-induced residual and recurrent tumours are the main cause of treatment failure in nasopharyngeal carcinoma (NPC). Thus, mechanisms NPC radioresistance predictive markers prognosis need to be investigated identified. In this study, we identified RPA3 as a candidate marker using RNA-seq samples. vitro studies further confirmed that affected radiosensitivity cells. Specifically, overexpression enhanced capacity for DNA repair cells, whereas inhibiting expression sensitized cells irradiation decreased capacity. Furthermore, RAD51 foci formation after irradiation. Immunohistochemical assays 104 specimens 21 normal epithelium indicated was significantly up-regulated tissues, log-rank test suggested patients with NPC, high associated shorter overall survival (OS) higher recurrence rate compared low (5-year OS rates: 67.2% versus 86.2%; 5-year 14.8% 2.3%). Moreover, TCGA data also correlated poor head neck squamous cell (HNSC) radiotherapy. Taken together, results our study demonstrated regulated may serve new biomarker help guide diagnosis individualized NPC.