Well-differentiated liposarcoma (atypical lipomatous tumors).

摘要: Well-differentiated (WD) liposarcoma accounts for about 40% to 45% of all liposarcomas therefore representing the larger subgroup adipocytic malignancies. It tends occur equally in retroperitoneum or limbs followed by paratesticular area and mediastinum, with a peak incidence between fifth seventh decades. WD is further subdivided (lipoma-like), sclerosing, inflammatory, spindle cell subtypes, which first two are far commoner. composed relatively mature proliferation, featuring size variation as well at least focal nuclear atypia. A varying number (from many none) lipoblasts may be found. Sclerosing characterized microscopically presence scattered distinctive bizarre stromal cells multivacuolated set fibrillary collagenous background. Inflammatory represents rare variant chronic inflammatory infiltrate predominates extent that differential diagnosis mainly nonadipocytic lesions such myofibroblastic tumor, Castleman's disease, Hodgkin's non-Hodgkin's lymphomas. Spindle rarest neural-like proliferation fibrous and/or myxoid background associated an atypical lipomatous component usually includes lipoblasts. Cytogenetically, appears homogenous exhibiting characteristic ring giant marker chromosomes containing amplified genetic material derived from 12q13-15 chromosome region. As any type have no potential metastasis unless they undergo dedifferentiation, opportunity replace term "WD liposarcoma" less frightening denomination has produced long, sharp debate. lipoma should considered synonyms their use determined degree reciprocal comprehension surgeon pathologist prevent either inadequate excessive treatment.