Molecular Biology of Acute Lymphoblastic Leukemia
作者： Małgorzata Dawidowska , Monika D. Kraszewska , Katarzyna Derwich , Tomasz Szczepański
DOI: 10.1007/978-3-642-29467-9_1
关键词: Pharmacogenetics 、 Medicine 、 Oncology 、 Leukemia 、 Gene expression profiling 、 Malignancy 、 Microarray 、 Internal medicine 、 Minimal residual disease 、 Gene rearrangement 、 Single-nucleotide polymorphism
摘要: Acute lymphoblastic leukemia (ALL) is the most common but also successfully treated malignancy in children. Current cure rates of approximately 85 % have been reached through multi-agent therapeutic regimens and particularly risk-stratification enabling therapy individualization. Nevertheless, relapse still main cause treatment failure. Therefore, effort now focused on improving outcome high risk ALL subtypes, i.e., Ph + ALL, infant with MLL gene rearrangements, hypodiploid some T-ALL subsets, recurrent refractory leukemia. Recent research using advanced molecular techniques, particular microarray-based genomic expression profiling (GEP) resolution single nucleotide polymorphism (SNP) microarray approaches, resulted identification novel genetic factors a potential impact classification treatment. The goal to translate these findings blast biology those pharmacogenetics patient response into improved diagnostics, prognostic classification, this malignancy.
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