CD4+NKG2D+ T Cells in Crohn’s Disease Mediate Inflammatory and Cytotoxic Responses Through MICA Interactions
作者： Matthieu Allez , Vannary Tieng , Atsushi Nakazawa , Xavier Treton , Vincent Pacault
DOI: 10.1053/J.GASTRO.2007.03.025
关键词: CD8 、 Immunology 、 Major histocompatibility complex 、 NKG2D 、 Immune system 、 Cytotoxic T cell 、 Intraepithelial lymphocyte 、 Biology 、 Lamina propria 、 Peripheral blood lymphocyte
摘要: Background & Aims: Crohn's disease (CD) is an inflammatory bowel characterized by uncontrolled immune responses to bacterial flora, with excessive activation of T lymphocytes. MICA a stress-induced major histocompatibility complex–related molecule expressed on normal intestinal epithelial cells (IECs) and recognized the NKG2D-activating receptor CD8 + cells, γδ natural killer cells. We examined role MICA-NKG2D interactions in lymphocytes CD. Methods: expression was analyzed flow cytometry IECs isolated from patients active controls. NKG2D function were lamina propria peripheral blood Results: significantly increased CD, higher macroscopically involved areas. A subset CD4 expressing CD compared controls ulcerative colitis. Th1 cytokine profile perforin periphery mucosa T-cell clones functionally through interactions, producing interferon-γ killing targets MICA. had ability expand this vitro. highly interleukin-15Rα, interleukin-15 DAP10 clones. Conclusions: These findings highlight unique cytotoxic properties
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Jeroen van Bergen, Allan Thompson, Arno van der Slik, Tom H. M. Ottenhoff, Jacobijn Gussekloo, Frits Koning, Phenotypic and Functional Characterization of CD4 T Cells Expressing Killer Ig-Like Receptors Journal of Immunology. ,vol. 173, pp. 6719- 6726 ,(2004) , 10.4049/JIMMUNOL.173.11.6719
Veronika Groh, Rebecca Rhinehart, Julie Randolph-Habecker, Max S. Topp, Stanley R. Riddell, Thomas Spies, Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC induced on virus-infected cells. Nature Immunology. ,vol. 2, pp. 255- 260 ,(2001) , 10.1038/85321
Jens Brimnes, Matthieu Allez, Iris Dotan, Ling Shao, Atsushi Nakazawa, Lloyd Mayer, Defects in CD8+ Regulatory T Cells in the Lamina Propria of Patients With Inflammatory Bowel Disease Journal of Immunology. ,vol. 174, pp. 5814- 5822 ,(2005) , 10.4049/JIMMUNOL.174.9.5814
P. Rutgeerts, K. Geboes, G. Vantrappen, J. Beyls, R. Kerremans, M. Hiele, Predictability of the postoperative course of Crohn's disease Gastroenterology. ,vol. 99, pp. 956- 963 ,(1990) , 10.1016/0016-5085(90)90613-6
Robert M Hershberg, Lloyd F Mayer, Antigen processing and presentation by intestinal epithelial cells – polarity and complexity Immunology Today. ,vol. 21, pp. 123- 128 ,(2000) , 10.1016/S0167-5699(99)01575-3
Arlette Darfeuille-Michaud, Christel Neut, Nicolas Barnich, Emmanuel Lederman, Patrick Di Martino, Pierre Desreumaux, Luc Gambiez, Bernard Joly, Antoine Cortot, Jean-Frédéric Colombel, Presence of adherent Escherichia coli strains in ileal mucosa of patients with Crohn's disease Gastroenterology. ,vol. 115, pp. 1405- 1413 ,(1998) , 10.1016/S0016-5085(98)70019-8
Alexander Steinle, Pingwei Li, Daniel L. Morris, Veronika Groh, Lewis L. Lanier, Roland K. Strong, Thomas Spies, Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family. Immunogenetics. ,vol. 53, pp. 279- 287 ,(2001) , 10.1007/S002510100325
L Mayer, D Eisenhardt, Lack of induction of suppressor T cells by intestinal epithelial cells from patients with inflammatory bowel disease. Journal of Clinical Investigation. ,vol. 86, pp. 1255- 1260 ,(1990) , 10.1172/JCI114832
Charles O. Elson, Yingzi Cong, Vance J. McCracken, Reed A. Dimmitt, Robin G. Lorenz, Casey T. Weaver, Experimental Models of Inflammatory Bowel Disease Reveal Innate, Adaptive, and Regulatory Mechanisms of Host Dialogue With the Microbiota Immunological Reviews. ,vol. 206, pp. 260- 276 ,(2005) , 10.1111/J.0105-2896.2005.00291.X
Markus F. Neurath, Susetta Finotto, Laurie H. Glimcher, The role of Th1/Th2 polarization in mucosal immunity Nature Medicine. ,vol. 8, pp. 567- 573 ,(2002) , 10.1038/NM0602-567