Are there changes in characteristics and therapy of young patients with early-onset breast cancer in Germany over the last decade?

摘要: The objective of the study is to investigate recent changes in patient characteristics and treatment procedures young breast cancer patients over last 10 years Germany. describes data 518 who were treated adjuvantly between 2008 2011 participated a resident mother–child program for rehabilitation (cohort II). includes TNM-categories, biology tumor therapies. This population compared cohort 535 patients, 2002 2006 I). Characteristics II are with normally age distributed cohort. 51.5 % diagnosed category pT1, 36.9 % pT2, 4.4 % pT3 1.2 % pT4. 3.3 % had merely DCIS. 58.1 % pN0, 28.4 % pN1 13.5 % more intense manifestation lymph nodes. 45.8 % tumors showed grading classified as G3, 69.3 % estrogen progesterone hormone receptor positive 21.8 % Her2 positive. 24.5 % examined triple negative carcinoma. 66.2 % pT1 or pT2 underwent breast-conserving surgery. Overall 19.2 % women received mastectomy only 17.4 % subsequent reconstruction. 98.6 % axillary surgery, 87.6 % chemotherapy. Overall, 21.0 % their chemotherapy connection clinical studies. 88.0 % endocrine therapy, 25.5 % them GnRH-analogs. In comparison I detected higher proportion nodes (48.8 %/58.1 %, p = 0.008) G1 (4.9/5.6 %, p = 0.001). On other hand percentage increased from (p = 0.018). Operative therapy has adjusted moderate way. Breast-conserving increases 57.3 % (p = 0.006), sentinel node biopsy 47.5 % (p‹0.001) years. percentages chemotherapy, radiation, antibody have stayed stable decade. Comparing group (DMP 2007–2009) still much lower portion (58.1 %/67.9 %) status (69.3 %/85.1 %). high G3 versus 24.7 % DMP II. 68.9 82.2 % comparatively low. Young surgery (98.6 %/81.5 %) but less (93.3 %/94.7 %). Germany can be regarded special group. Although now often before reaching than ago, an even bigger negative. improved aggressive Still operative medical treatments chosen after very careful evaluation.