Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients.

作者： Christian Nicolaj Andreassen , Barry S Rosenstein , Sarah L Kerns , Harry Ostrer , Dirk De Ruysscher

DOI: 10.1016/J.RADONC.2016.06.017

关键词: Radiogenomics 、 Medicine 、 Prostate cancer 、 Acute toxicity 、 Toxicity 、 Radiation therapy 、 Pathology 、 Breast cancer 、 Single-nucleotide polymorphism 、 Oncology 、 Odds ratio 、 Internal medicine

摘要: Abstract Purpose Several small studies have indicated that the ATM rs1801516 SNP is associated with risk of normal tissue toxicity after radiotherapy. However, findings not been consistent. In order to test this in a well-powered study, an individual patient data meta-analysis was carried out by International Radiogenomics Consortium. Materials and methods The analysis included 5456 patients from 17 different cohorts. 2759 were given radiotherapy for breast cancer 2697 prostate cancer. Eight scores (overall toxicity, acute late skin rectal telangiectasia, fibrosis toxicity) analyzed. Adjustments made treatment related factors potential impact on toxicity. Results For all endpoints except significantly increased found carriers minor (Asn) allele odds ratios approximately 1.5 1.2 results consistent co-dominant pattern inheritance. Conclusion This study convincingly showed significant association between Asn radiation-induced

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Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients.

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Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients.

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