Calcification of porcine and human cardiac valves: testing of various inhibitors for antimineralization.
作者： S. Koutsopoulos , A. Kontogeorgou , E. Dalas , J. Petroheilos
关键词: Amino acid 、 Materials science 、 Pharmacology 、 Heart valve 、 Biochemistry 、 Aspartic acid 、 Reduced mineralization 、 Cardiac valve 、 Phenylalanine 、 Glutamic acid 、 Calcification
摘要: Despite distinct advantages over mechanical cardiac valve prostheses, the use of bioprosthetic valves remains limited, due to poor long-term durability, primarily as a result tissue calcification. A novel in vitro, anticalcification process based on treatment porcine and human heart with metallocene dichlorides, well amino acids (phenylalanine, aspartic acid, glutamic acid), has been developed. This reduced mineralization up 32% 28%, respectively.
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