Norovirus Vaccine against Experimental Human Norwalk Virus Illness

摘要: Background Noroviruses cause epidemic and sporadic acute gastroenteritis. No vaccine is available to prevent norovirus illness or infection. Methods We conducted a randomized, double-blind, placebo-controlled, multicenter trial assess the safety, immunogenicity, efficacy of an investigational, intranasally delivered viruslike particle (VLP) (with chitosan monophosphoryl lipid A as adjuvants) viral gastroenteritis after challenge with homologous strain, Norwalk virus (genotype GI.1). Healthy adults 18 50 years age received two doses either placebo were subsequently inoculated monitored for infection symptoms. Results Ninety-eight persons enrolled randomly assigned receive (50 participants) (48 participants), 90 both (47 participants in group 43 group). The most commonly reported symptoms vaccination we...