Pharmacokinetic-pharmacodynamic model for the reversal of neuromuscular blockade by sugammadex.

摘要: Background Sugammadex selectively binds steroidal neuromuscular blocking drugs, leading to reversal of blockade. The authors developed a pharmacokinetic-pharmacodynamic model for blockade by sugammadex, assuming that results from decrease free drug in plasma and/or junction. was applied predicting the interaction between sugammadex and rocuronium or vecuronium. Methods Noninstantaneous equilibrium rocuronium-sugammadex complex formation assumed model. pharmacokinetic parameters alone were be identical. After development alone, optimized using concentration data after administration 0.1-8 mg/kg 3 min 0.6 rocuronium. Subsequently, predicted compared with up 8 at reappearance second twitch train-of-four; 3, 5, 15 Finally, predict vecuronium-induced Results Using vitro dissociation constants binding vecuronium adequately increase total concentrations time-course Conclusions Model-based evaluation supports hypothesis rocuronium- is useful prediction sugammadex.