Incompletely reverse-transcribed human immunodeficiency virus type 1 genomes in quiescent cells can function as intermediates in the retroviral life cycle.

作者: J A Zack , A M Haislip , P Krogstad , I S Chen

DOI: 10.1128/JVI.66.3.1717-1725.1992

关键词: VirusReverse transcriptaseMolecular biologyMultiplicity of infectionViral replicationDNA synthesisReverse Transcription ProcessBiologyLymphocyteReal-time polymerase chain reaction

摘要: … 4), we conclude that the partially reversetranscribed viral species is an intermediate that can be induced to form progeny virus following mitogenic stimulation of infected quiescent …

参考文章(21)
M. Stevenson, T.L. Stanwick, M.P. Dempsey, C.A. Lamonica, HIV-1 replication is controlled at the level of T cell activation and proviral integration. The EMBO Journal. ,vol. 9, pp. 1551- 1560 ,(1990) , 10.1002/J.1460-2075.1990.TB08274.X
J P Dougherty, R Wisniewski, S L Yang, B W Rhode, H M Temin, New retrovirus helper cells with almost no nucleotide sequence homology to retrovirus vectors. Journal of Virology. ,vol. 63, pp. 3209- 3212 ,(1989) , 10.1128/JVI.63.7.3209-3212.1989
A Kinter, J Justement, R Redfield, S Benn, J Kelly, A S Fauci, T Folks, J Gold, K W Sell, Susceptibility of normal human lymphocytes to infection with HTLV-III/LAV. Journal of Immunology. ,vol. 136, pp. 4049- 4053 ,(1986)
A Adachi, H E Gendelman, S Koenig, T Folks, R Willey, A Rabson, M A Martin, Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone. Journal of Virology. ,vol. 59, pp. 284- 291 ,(1986) , 10.1128/JVI.59.2.284-291.1986
Eric H. Humphries, Howard M. Temin, Requirement for Cell Division for Initiation of Transcription of Rous Sarcoma Virus RNA Journal of Virology. ,vol. 14, pp. 531- 546 ,(1974) , 10.1128/JVI.14.3.531-546.1974