Methionine sulfoxide reductase B3 deficiency inhibits cell growth through the activation of p53-p21 and p27 pathways.
作者： Eujin Lee , Geun-Hee Kwak , Kranti Kamble , Hwa-Young Kim
DOI: 10.1016/J.ABB.2014.02.008
关键词: Cell cycle checkpoint 、 Kinase 、 Cell biology 、 Oxidoreductase 、 Regulator 、 Molecular biology 、 Biology 、 Cell growth 、 Methionine sulfoxide reductase 、 Methionine 、 Endoplasmic reticulum
摘要: Methionine sulfoxide reductase B3 (MsrB3) is an oxidoreductase in the endoplasmic reticulum that catalyzes stereospecific reduction of methionine-R-sulfoxide to methionine. Here, we report critical role and mechanisms MsrB3 cell proliferation. The deletion led a significant decrease proliferation mouse embryonic fibroblast (MEF) cells. MsrB3-knockout MEF cells showed increased p53 protein levels, compared wild-type cells, which subsequently elevated level cyclin-dependent kinase inhibitor p21. In addition, deficiency enhanced p27, another cycle regulator, caused arrest at G1 stage. inhibitory effect on through activation p53-p21 p27 pathways was also confirmed primary human dermal fibroblasts. Collectively, data suggest regulator growth pathways.
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