Lithium selectively potentiates cholinergic activity in rat brain.

摘要: Publisher Summary Lithium is one of the most effective drugs available for treatment psychiatric disorders, as it therapeutic in approximately 80% manic-depressive patients and reduces manifestations both phases illness. Thus, intriguing conjugation simplest drug known to man effectively treating disorders great complexity, those involving emotion behavior. a mood-stabilizer; seems support homeostatic mechanisms that strive maintain balance responses stimuli, which cause fluctuations mood. learning mechanism action lithium may increase understanding neurochemical basis related disorders. This chapter describes experimental results, show selectively increases cholinergic activity mammalian brain vivo . Furthermore, at appropriate doses, co-administration cholinomimetics results seizures, are generalized all regions have been examined, difficult control pharmacologically, leading invariably death. A tremendously large concentrations acetylcholine choline accompany do products phosphoinositide second messenger system. Potential might mediate stimulatory effects on function discussed.