Hepatitis B Virus X Protein: Structure-Function Relationships and Role in Viral Pathogenesis
作者： V. Kumar , D. P. Sarkar
DOI: 10.1007/978-3-642-18932-6_12
关键词: Biology 、 HBx 、 Orthohepadnavirus 、 Viral pathogenesis 、 Protein degradation 、 Hepatitis B virus 、 Hepatitis 、 Hepadnaviridae 、 RNA interference 、 Virology
摘要: The hepatitis B virus (HBV) genome codes for a 16.5-KDa protein termed pX or HBx which is prevalent marker in the liver of patients with hepatit B-associated hepatocellular carcinoma (HCC). Although specific function natural infection remains elusive, it considered to play an important role etiology HBV-induced HCC. It multifunctional regulatory that best characterized as promiscuous transactivator. can induce different signaling pathways, deregulate cell cycle checkpoint s even adapt responses genotoxic stress and degradation. oncogenic nature evident from its ability transform permanent lines ex vivo liver-specific tumors transgenic animals. RNA interference against expression could be effective therapeutic tool management diseases.
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