The urokinase plasminogen activator system in cancer: recent advances and implication for prognosis and therapy.
作者： Nicolai Sidenius , Francesco Blasi
关键词: Biochemistry 、 Cell adhesion 、 Vitronectin 、 Plasmin 、 Integrin 、 Extracellular matrix 、 Plasminogen activator 、 Urokinase receptor 、 Proteolytic enzymes 、 Cell biology 、 Biology
摘要: Cancer dissemination and metastasis is synonymous with invasive cell migration; a process in which the extracellular matrix (ECM) plays dual role of substratum on cells move as well physical obstacle that have to surpass. To degrade obstacle, ECM poses direction migration, use proteolytic enzymes capable degrading components. A major protease system responsible for degradation plasminogen activation system, generates potent serine plasmin. The subject this review, urokinase-type activator (uPA) its receptor (uPAR), an impressive range distinct, but overlapping functions cancer invasion metastasis: Firstly, uPA/uPAR promotes proteolysis by regulating activation. Secondly, regulates cell/ECM interactions adhesion vitronectin (Vn) through capacity modulate integrin function. Thirdly, migration signal transduction molecule intrinsic chemotactic activity. This review focused recent insight into related biology implications clinical diagnosis, prognosis therapy.
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