Prospective Study of Coronary Heart Disease Incidence in Relation to Fasting Total Homocysteine, Related Genetic Polymorphisms, and B Vitamins
作者： Aaron R. Folsom , F. Javier Nieto , Paul G. McGovern , Michael Y. Tsai , M. René Malinow
关键词: Relative risk 、 Pyridoxal 、 Homocysteine 、 Risk factor 、 Prospective cohort study 、 B vitamins 、 Medicine 、 Internal medicine 、 Endocrinology 、 Incidence (epidemiology) 、 Cohort study 、 Physiology (medical) 、 Cardiology and Cardiovascular Medicine
摘要: Background—Elevated plasma total homocysteine (tHcy), low B-vitamin intake, and genetic polymorphisms related to tHcy metabolism may play roles in coronary heart disease (CHD). More prospective studies are needed. Methods Results—We used a case-cohort design determine whether tHcy-related factors associated with incidence of CHD over an average 3.3 years follow-up biracial sample middle-aged men women. Age-, race-, field center–adjusted was positively (P<0.05) women but not men, negatively folate (women only), pyridoxal 5′-phosphate (both sexes), vitamin supplementation only). However, after accounting for other risk factors, only incidence; the relative highest versus lowest quintile 0.28 (95% CI=0.1 0.7). There no association C677T mutation of...
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