β-glucan recognition by the innate immune system
作者： Helen S. Goodridge , Andrea J. Wolf , David M. Underhill
DOI: 10.1111/J.1600-065X.2009.00793.X
关键词: Biology 、 Signal transduction 、 Inflammation 、 Immunology 、 Acquired immune system 、 Immune system 、 Pattern recognition receptor 、 CCL18 、 Neuroscience 、 Macrophage 、 Innate immune system 、 Immunology and Allergy
摘要: Beta-glucans are recognized by the innate immune system. This recognition plays important roles in host defense and presents specific opportunities for clinical modulation of response. Neutrophils, macrophages, dendritic cells among others express several receptors capable recognizing beta-glucan its various forms. review explores what is currently known about how this stimulates responses. Special emphasis placed on Dectin-1, as we know most key receptor translates into intracellular signaling, cellular responses, participates orchestrating adaptive
sci-hub.se 参考文章(96)
Jiří Manych, Aspergillosis Infectious Disease Clinics of North America. ,vol. 16, pp. 875- 894 ,(2002) , 10.1016/S0891-5520(02)00035-1
Scott D. Blystone, Eric J. Brown, Integrin receptors of phagocytes Advances in Cellular and Molecular Biology of Membranes and Organelles. ,vol. 5, pp. 103- 147 ,(1999) , 10.1016/S1874-5172(99)80030-3
Vaibhav B. Shah, Yongcheng Huang, Rohan Keshwara, Tammy Ozment-Skelton, David L. Williams, Lakhu Keshvara, β-Glucan Activates Microglia without Inducing Cytokine Production in Dectin-1-Dependent Manner Journal of Immunology. ,vol. 180, pp. 2777- 2785 ,(2008) , 10.4049/JIMMUNOL.180.5.2777
A. L. Kindzelskii, Wei Xue, Robert F. Todd, Howard R. Petty, Physical association of complement receptor type 3 and urokinase-type plasminogen activator receptor in neutrophil membranes. Journal of Immunology. ,vol. 152, pp. 4630- 4640 ,(1994)
Sigrid E. M. Heinsbroek, Philip R. Taylor, Marcela Rosas, Janet A. Willment, David L. Williams, Siamon Gordon, Gordon D. Brown, Expression of Functionally Different Dectin-1 Isoforms by Murine Macrophages Journal of Immunology. ,vol. 176, pp. 5513- 5518 ,(2006) , 10.4049/JIMMUNOL.176.9.5513
Geoffrey M. Gersuk, David M. Underhill, Liqun Zhu, Kieren A. Marr, Dectin-1 and TLRs Permit Macrophages to Distinguish between Different Aspergillus fumigatus Cellular States Journal of Immunology. ,vol. 176, pp. 3717- 3724 ,(2006) , 10.4049/JIMMUNOL.176.6.3717
Helen S. Goodridge, Randi M. Simmons, David M. Underhill, Dectin-1 Stimulation by Candida albicans Yeast or Zymosan Triggers NFAT Activation in Macrophages and Dendritic Cells Journal of Immunology. ,vol. 178, pp. 3107- 3115 ,(2007) , 10.4049/JIMMUNOL.178.5.3107
David M. Underhill, Adrian Ozinsky, Adeline M. Hajjar, Anne Stevens, Christopher B. Wilson, Michael Bassetti, Alan Aderem, The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens Nature. ,vol. 401, pp. 811- 815 ,(1999) , 10.1038/44605
Xia Y, Mayadas T, Ross Gd, Yan J, Hanikýrová M, Vetvicka, The beta-glucan-binding lectin site of mouse CR3 (CD11b/CD18) and its function in generating a primed state of the receptor that mediates cytotoxic activation in response to iC3b-opsonized target cells. Journal of Immunology. ,vol. 162, pp. 2281- 2290 ,(1999)
Mihai G. Netea, Roger Sutmuller, Corinna Hermann, Chantal A. A. Van der Graaf, Jos W. M. Van der Meer, Johan H. van Krieken, Thomas Hartung, Gosse Adema, Bart Jan Kullberg, Toll-Like Receptor 2 Suppresses Immunity againstCandida albicansthrough Induction of IL-10 and Regulatory T Cells The Journal of Immunology. ,vol. 172, pp. 3712- 3718 ,(2004) , 10.4049/JIMMUNOL.172.6.3712