Screening for the antidepressant activity of some species of Hypericum from South Brazil
作者： R. Daudt , G. L. von Poser , G. Neves , S. M. K. Rates
DOI: 10.1002/1099-1573(200008)14:5<344::AID-PTR586>3.0.CO;2-3
关键词: Pharmacognosy 、 Biological activity 、 Chloroform 、 Traditional medicine 、 Hypericum 、 Phytotherapy 、 Petroleum ether 、 Phloroglucinol 、 Biology 、 Medicinal plants
摘要: An Erratum has been published for this article in Phytotherapy Research 14(8) 2000, 661. The crude methanol extracts of three species the genus Hypericum (H. brasiliense, H. caprifoliatum and myrianthum) native to South Brazil were evaluated antidepressant activity according forced swimming test, a classical animal model drug screening. Among studied, only showed activity. Thus, plant was fractionated with solvents increasing polarity (petroleum ether; petroleum ether: chloroform (1:1); methanol). The ether fraction one which demonstrated at dose 270 mg/kg/day (i.p.). chemical analyses that is rich phenolic compounds, mainly phloroglucinol type. Copyright © 2000 John Wiley & Sons, Ltd.
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