Raman Plus X: Biomedical Applications of Multimodal Raman Spectroscopy.

摘要: Raman spectroscopy is a label-free method of obtaining detailed chemical information about samples. Its compatibility with living tissue makes it an attractive choice for biomedical analysis, yet its translation from research tool to clinical has been slow, hampered by fundamental scattering issues such as long integration times and limited penetration depth. In this review we detail the how combining other techniques yields multimodal instruments that can help surmount translational barriers faced alone. We combined several optical non-optical methods, including fluorescence, elastic scattering, OCT, phase imaging, mass spectrometry. each section highlight power combination along brief history presentation representative results. Finally, conclude perspective detailing both benefits challenges measurements, give thoughts on future directions in field.