Combination effect on HIV infection in vitro of soluble CD4 and HIV-neutralizing antibodies

作者: J. -E. S. Hansen , A. M. S�rensen , S. Olofsson , E. Osinaga , A. Roseto

DOI: 10.1007/BF01379116

关键词: VirusVirologyInfectivityIn vitroMedical microbiologyMonoclonal antibodyNeutralizationAntibodyBiologyAntagonism

摘要: In combination with HIV gp120 V3-loop antibody, two carbohydrate specific neutralizing antibodies (83D4 and 2G12) had a synergistic effect on infection. However, sCD4 an antibody which blocks gp 120/CD4 binding (1B1) both displayed antagonism.

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