Function, location, and regulation of the src protein-tyrosine kinase.

摘要: The physiological roles, precise locations, and relevant targets of the 60 kD protein-tyrosine kinase encoded by viral cellular src genes p60src are not known, despite intensive study. We describe recent work that bears upon these unresolved problems: (i) p60c-src is phosphorylated during mitosis on threonine serine residues protein mammalian homologue cdc2, suggesting c-src may contribute to phenotype mitotic cells; (ii) multiple regions in amino-terminal portion required for its proper intracellular localization--a short signal myristylation signals association with cytoplasmic granules perinuclear plasma membranes; (iii) (called SH3 SH2) upstream domain modulate behavior complex ways, some mutations SH2 rendering p60 host-dependent transformation. latter mutants prove be powerful tools identifying proteins modify or serve as src-encoded kinases.