Impact of obesity on treatment of chronic hepatitis C
作者： Michael R. Charlton , Paul J. Pockros , Stephen A. Harrison
DOI: 10.1002/HEP.21239
关键词: Insulin resistance 、 Gastroenterology 、 Hepatitis C 、 Liver disease 、 Ribavirin 、 Nonalcoholic fatty liver disease 、 Steatosis 、 Metabolic syndrome 、 Medicine 、 Internal medicine 、 Fibrosis
摘要: Obesity and the metabolic syndrome have hepatic manifestations, including steatosis progression of fibrosis. In individuals with chronic hepatitis C, obesity is associated inflammation, insulin resistance, steatosis, fibrosis, nonresponse to treatment interferon or peginterferon alpha ribavirin. Patients both C obesity-related nonalcoholic fatty liver disease are at greater risk for more advanced disease. We review mechanisms by which may be decreased efficacy interferon-based therapies in therapeutic strategies that increase effectiveness these obese individuals.
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