Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis
作者： Menq-Jer Lee , Shobha Thangada , Ji-Hye Paik , Gopal P. Sapkota , Nicolas Ancellin
DOI: 10.1016/S1097-2765(01)00324-0
关键词: Cell biology 、 Chemotaxis 、 G protein-coupled receptor kinase 、 G protein-coupled receptor 、 Biology 、 Phosphorylation 、 Protein kinase B 、 Akt/PKB signaling pathway 、 Endothelial cell chemotaxis 、 Transactivation
摘要: … In this report, we show that Akt activity is required for EDG-1 to activate Rac. Akt and Rac are involved in … Since EDG-1 phosphorylation by Akt is needed for Rac activation, it is likely that …
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