Characterization of protein glycosylation by mass spectrometry
作者： Alma L Burlingame
DOI: 10.1016/S0958-1669(96)80088-7
关键词: Top-down proteomics 、 Collision-induced dissociation 、 Mass spectrometry 、 Chromatography 、 Sample preparation in mass spectrometry 、 Chemistry 、 Protein mass spectrometry 、 Selected reaction monitoring 、 Analytical chemistry 、 Direct electron ionization liquid chromatography–mass spectrometry interface 、 Electrospray ionization
摘要: Electrospray ionization, a natural interface with microbore and capillary high-pressure liquid chromatography, has become the method of choice for reliable structural characterization protein glycosylation by mass spectrometry at picomole level. Its advantages include inherent sensitivity in femtomole range, compatibility collisional activation methods that both permit detection monitoring structurally specific ions enable induction glycopeptide fragmentation facilitates determination glycoform sequence branching. Developments high-performance electrospray sample introduction nanoliter flow rates, tandem magnetic sector/orthogonal time-of-flight instruments, Fourier transform new ion optical strategies, including traps. Although sensitive important complementary technique, matrix-assisted laser desorption/ionization suffers from matrix-dependent deposition excess internal energies, which produce extensive metastable (photo)adduct formation. These fragments may be focused into spectrum employing an mirror (reflectron) instrumentation. In favorable cases, information obtained.
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