Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19.
作者： Robert L. Hoffman , Robert S. Kania , Mary A. Brothers , Jay F. Davies , Rose A. Ferre
DOI: 10.1021/ACS.JMEDCHEM.0C01063
关键词: Vero cell 、 Proteases 、 Cysteine protease 、 Polyproteins 、 Genome 、 Chemistry 、 Coronavirus 、 Ketone 、 Virology 、 Plasma protein binding
摘要: … The 3CL pro sequences for CoV-1 and CoV-2 viruses are … ketone-based inhibitors of SARS CoV-1 3CL pro employing … 00835231) as a potent inhibitor of CoV-2 3CL pro with suitable …
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Karin E. Limburg, Mary Ann Moran, Synthesis and Evaluation Springer, New York, NY. pp. 155- 172 ,(1986) , 10.1007/978-1-4612-4874-3_6
Michael P. Gamcsik, J. Paul G. Malthouse, William U. Primrose, Neil E. Mackenzie, Alan S. F. Boyd, Richard A. Russell, A. Ian Scott, Structure and stereochemistry of tetrahedral inhibitor complexes of papain by direct NMR observation Journal of the American Chemical Society. ,vol. 105, pp. 6324- 6325 ,(1983) , 10.1021/JA00358A030
Zhaozhao Li, Girish S. Patil, Zbigniew E. Golubski, Hitoshi Hori, Kamin Tehrani, J. E. Foreman, David D. Eveleth, Raymond T. Bartus, James C. Powers, Peptide alpha-keto ester, alpha-keto amide, and alpha-keto acid inhibitors of calpains and other cysteine proteases. Journal of Medicinal Chemistry. ,vol. 36, pp. 3472- 3480 ,(1993) , 10.1021/JM00074A031
James Solowiej, James A. Thomson, Kevin Ryan, Chun Luo, Mingying He, Jihong Lou, Brion W. Murray, Steady-state and pre-steady-state kinetic evaluation of severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro cysteine protease: development of an ion-pair model for catalysis. Biochemistry. ,vol. 47, pp. 2617- 2630 ,(2008) , 10.1021/BI702107V
Peter S. Dragovich, Thomas J. Prins, Ru Zhou, Stephen E. Webber, Joseph T. Marakovits, Shella A. Fuhrman, Amy K. Patick, David A. Matthews, Caroline A. Lee, Clifford E. Ford, Benjamin J. Burke, Paul A. Rejto, Thomas F. Hendrickson, Tove Tuntland, Edward L. Brown, James W. Meador, Rose Ann Ferre, James E. V. Harr, Maha B. Kosa, Stephen T. Worland, Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 4. Incorporation of P1 lactam moieties as L-glutamine replacements. Journal of Medicinal Chemistry. ,vol. 42, pp. 1213- 1224 ,(1999) , 10.1021/JM9805384
Owen S. Weislow, Rebecca Kiser, Donald L. Fine, John Bader, Robert H. Shoemaker, Michael R. Boyd, New Soluble-Formazan Assay for HIV-1 Cytopathic Effects: Application to High-Flux Screening of Synthetic and Natural Products for AIDS-Antiviral Activity Journal of the National Cancer Institute. ,vol. 81, pp. 577- 586 ,(1989) , 10.1093/JNCI/81.8.577
Kenneth D Brady, David A Giegel, Christine Grinnell, Elizabeth Lunney, Robert V Talanian, Winnie Wong, Nigel Walker, A catalytic mechanism for caspase-1 and for bimodal inhibition of caspase-1 by activated aspartic ketones. Bioorganic & Medicinal Chemistry. ,vol. 7, pp. 621- 631 ,(1999) , 10.1016/S0968-0896(99)00009-7
James C. Powers, Juliana L. Asgian, Özlem Doǧan Ekici, Karen Ellis James, Irreversible inhibitors of serine, cysteine, and threonine proteases. Chemical Reviews. ,vol. 102, pp. 4639- 4750 ,(2002) , 10.1021/CR010182V
Roger A. Smith, Leslie J. Copp, Peter J. Coles, Henry W. Pauls, Valerie J. Robinson, Robin W. Spencer, Stephen B. Heard, Allen. Krantz, New inhibitors of cysteine proteinases. Peptidyl acyloxymethyl ketones and the quiescent nucleofuge strategy Journal of the American Chemical Society. ,vol. 110, pp. 4429- 4431 ,(1988) , 10.1021/JA00221A062
Hans-Hartwig Otto, Tanja Schirmeister, Cysteine Proteases and Their Inhibitors. Chemical Reviews. ,vol. 97, pp. 133- 172 ,(1997) , 10.1021/CR950025U