Assessing Residual Cone Function in Retinitis Pigmentosa Patients

摘要: Purpose The purpose of this study was to investigate cone function deterioration in patients with retinitis pigmentosa (RP) using full field electroretinogram (ffERG), pattern (pERG), and optical coherence tomography (OCT) their correlation visual acuity (VA). Methods Clinical records (2008-2018) RP undergoing repeat electrophysiology were reviewed. Results ffERG (30 Hz flicker fused amplitude [FFAmp]), pERG [p50 n95], macular OCT (ellipsoid zone [EZ] outer segment thickness) collected. One hundred twenty-six eyes from 63 (33 women, mean age 35 years) included. decline VA 0.11 ± 0.14 logarithm minimum angle resolution (logMAR). FFAmp decreased by 3.01 5.9 µV global deteriorating 18.7% annually. percentage change (RE [r = 0.553], LE 0.531]), 30 0.615], 0.529]) strongly correlated (P < 0.00001). p50 (15 30 degrees) analyzed 34 showed reduction 23% 23.4%, respectively. 30 degrees (r 0.397) EZ layer 0.05). calculated 45 the shortening thinning rate 4.3% 4.4% annually, length 0.34] 0.466; P Conclusions We quantified utilizing measures residual function. These parameters when measurable. objective may assist monitoring disease progression. Translational Relevance Residual provides an estimate function, which aids counselling regarding prognosis.