Alterations in gene expression due to chronic lead exposure induce behavioral changes.

摘要: Abstract Lead (Pb) is a pollutant commonly found in the environment, despite implementation of public health policies intended to remove it. Due its chemical characteristics as divalent ion, Pb interacts with cells, enzymes, and tissues, causing pathological, physical, behavioral alterations. Recent biotechnological advances have helped us understand mechanisms underlying damage caused by human populations experimental models, new evidence on epigenetic alterations exposition environmental available. It known that exposure impacts behavior (causing aggressiveness, anxiety, depression), leading learning deficit locomotor activity alterations, presence has been linked abnormal release neurotransmitters other biochemical changes involved these disorders. Still, further reductionist studies are required determine effects DNA protein expression processes diseases Pb. This will also indicate possible therapeutic targets offset negative heavy metal. By elucidating involved, it would be manipulate them propose novel approaches this area. review aimed provide an overview link changes, well at neurotransmitter level, considering importance metal abnormalities.