Increased Steady-State Memory B Cell Subsets Among High-Risk Participants in an HIV Vaccine Trial.

摘要: The success of an HIV vaccine will require induction a protective immune response in the most at-risk populations. increased incidence infection high-risk populations is assumed to be primarily result more frequent exposure virus or greater inoculum virus; however, underlying variations homeostasis may also contribute susceptibility and potentially impact responses those required for protection. As effective humoral likely critical component vaccine, we evaluated steady-state phenotypic profile peripheral blood B cells by flow cytometry from participants Vaccine Trials Network (HVTN) 203 Phase 2a trial considered at higher risk lower acquisition. Overall, exhibited frequency unswitched IgM memory activated switched IgD-CD95+ than low-risk participants. Most (93%) male were men who have sex with engaged sexual behavior. High-risk males had significantly CXCR3+ males. These results suggest that altered cell homeostasis. activation populations, which possible differential strategies.