Donor human leukocyte antigen-G single nucleotide polymorphisms are associated with post-lung transplant mortality.

摘要: Human leukocyte antigen (HLA)-G is a non-classical HLA that inhibits immune responses. Its expression modified by single nucleotide polymorphisms (SNPs), which are associated with transplant outcomes. Our aim was to investigate the association of donor and recipient HLA-G SNPs chronic lung allograft dysfunction (CLAD) mortality after transplantation. In this single-centre study, we examined 11 in 345 consecutive recipients 297 donors first bilateral transplant. A multivariable Cox proportional hazards model assessed associations death CLAD. Transbronchial biopsies (TBBx) bronchoalveolar lavage (BAL) samples were using quantitative PCR, ELISA immunofluorescence. Over median 4.75 years, 142 patients (41%) developed CLAD; 170 (49%) died. Multivariable analysis revealed SNP +3142 (GG+CG versus CC) increased (hazard ratio 1.78, 95% CI 1.12–2.84; p=0.015). contrast, five SNPs, -201(CC), -716(TT), -56(CC), G*01:03(AA) 14 bp INDEL, conferred reduced risk. Specific donor–recipient pairings CLAD Predominantly epithelial observed on TBBx without rejection. Soluble present higher concentrations BAL patients who later risk transplantation, while certain modulated demonstrated predominantly epithelial, therefore presumably donor-derived, keeping these observations. This study demonstrate an effect transplantation outcome.