Association of Epstein-Barr Virus with Hodgkin’s Disease

摘要: The nature of Hodgkin’s disease (HD) and the origin its characteristic cells, Reed-Sternberg (RS) are still obscure in spite abundant literature on this disorder. In recent years, concept that HD is a malignant lymphoma has become widely accepted among pathologists, clinicians, medical researchers working disease. However, evidence accumulated so far with regard to standard parameters defining neoplastic proliferation, such as clonality, chromosomal abnormality, transplantability, controversial. A further enigma concerning lymphoproliferative extremely low percentage putative cells (RS their variants) occurring polymorphic histopathological setting characterizes contrast, well-recognized diseases, so-called non-Hodgkin’s lymphomas (NHLs), usually show monomorphic histological patterns constituted predominantly monoclonal or, more rarely, oligoclonal cell populations.