Methods and compositions relating to hematologic malignancies
作者： Shaoguang Li
DOI:
关键词: Stem cell 、 Medicine 、 Pharmacology 、 Leukemia
摘要: Methods of treating a subject having, or at risk myeloproliferative disorder are provided according to embodiments the present invention which include administering therapeutically effective amount an arachidonate 5-lipoxygenase (5-LO) inhibitor subject. Combinations therapeutic agents administered invention. In some embodiments, two more 5-LO inhibitors treat disorder. further least one and additional agent inhibiting leukemia stem cells contacting with inhibitor.
lens.org 参考文章(26)
John Lyons, Method for treating chronic myelogenous leukemia ,(2002)
Ashwani Kumar Verma, Shirumalla Raj Kumar, Abhijit Ray, Sanjay Malhotra, 5-lipoxygenase inhibitors ,(2007)
Marti Jett, James L. Mulshine, Use of lipoxygenase inhibitors as anti-cancer therapeutic and intervention agents ,(1995)
Haixiao Zhai, Changgeng Qian, Xiong Cai, Stephen Gould, Tyrosine kinase inhibitors containing a zinc binding moiety ,(2007)
Tareq Al Baghdadi, Rafat Abonour, H. Scott Boswell, Novel Combination Treatments Targeting Chronic Myeloid Leukemia Stem Cells Clinical Lymphoma, Myeloma & Leukemia. ,vol. 12, pp. 94- 105 ,(2012) , 10.1016/J.CLML.2011.10.003
Kenneth Hensley, Melinda West, Molina Mhatre, Alex Ceballos, Robert A. Floyd, Paula Grammas, S. Prasad Gabbita, Ladan Hamdheydari, Tammy Mai, Shenyun Mou, Quentin N. Pye, Charles Stewart, Stuart West, Kelly S. Williamson, Frank Zemlan, The arachidonic acid 5-lipoxygenase inhibitor nordihydroguaiaretic acid inhibits tumor necrosis factor alpha activation of microglia and extends survival of G93A-SOD1 transgenic mice. Journal of Neurochemistry. ,vol. 91, pp. 133- 143 ,(2004) , 10.1111/J.1471-4159.2004.02700.X
Mario Romano, Joan Clària, Cyclooxygenase-2 and 5-lipoxygenase converging functions on cell proliferation and tumor angiogenesis: implications for cancer therapy The FASEB Journal. ,vol. 17, pp. 1986- 1995 ,(2003) , 10.1096/FJ.03-0053REV
Yaoyu Chen, Yiguo Hu, Haojian Zhang, Cong Peng, Shaoguang Li, Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia Nature Genetics. ,vol. 41, pp. 783- 792 ,(2009) , 10.1038/NG.389
Yaoyu Chen, Dongguang Li, Shaoguang Li, The Alox5 gene is a novel therapeutic target in cancer stem cells of chronic myeloid leukemia. Cell Cycle. ,vol. 8, pp. 3488- 3492 ,(2009) , 10.4161/CC.8.21.9852
Con Sullivan, Cong Peng, Yaoyu Chen, Dongguang Li, Shaoguang Li, Targeted therapy of chronic myeloid leukemia. Biochemical Pharmacology. ,vol. 80, pp. 584- 591 ,(2010) , 10.1016/J.BCP.2010.05.001