Periostin, a Matricellular Protein, Plays a Role in the Induction of Chemokines in Pulmonary Fibrosis

摘要: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and usually fatal form of interstitial lung disease (ILD). The precise molecular mechanisms IPF remain poorly understood. However, analyses mice receiving bleomycin (BLM) as model established the importance preceding inflammation for formation fibrosis. Periostin recently characterized matricellular protein involved in modulating cell functions. We found that periostin highly expressed tissue patients with IPF, suggesting it may play role process To explore this possibility, we administered BLM to periostin-deficient mice, they subsequently showed reduction next determined whether result was caused by decrease recruitment neutrophils macrophages lungs because lower production chemokines proinflammatory cytokines. performed an vitro analysis chemokine productio...