Recombinant human insulin-like growth factor-I accelerates recovery and reduces catabolism in rats with ischemic acute renal failure.

摘要: Abstract This study evaluated whether recombinant human insulin-like growth factor-I (rhIGF-I) enhances recovery of renal function and reduces catabolism in rats with ischemic acute failure (ARF). ARF sham received subcutaneous injections either rhIGF-I or vehicle three times daily starting 5 h after surgery. Serum creatinine urea, which initially rose similarly the ARF+vehicle ARF+rhIGF-I rats, increased more slowly commencing injections. 72 surgery, comparison animals, showed significantly greater plasma flow filtration fraction, a fivefold higher glomerular rate, cortical IGF-I levels, proliferating cell nuclear antigen expression proximal tubule nuclei enhanced DNA synthesis cortex, corticomedullary junction, glomeruli, tubules as demonstrated by [3H]thymidine incorporation junction determined autoradiography. Estimated total nitrogen output (ETNO) was than throughout study. ETNO returned to values second day protein degradation reduced epitrochlearis muscle compared sham+vehicle rats. Thus, treatment inducing increases function, formation new tubular cells, lowers degradation, skeletal net catabolism.