作者: Govind Prasad Sah , Daniel Wall
DOI: 10.1016/J.MIB.2020.07.003
关键词: Bacterial outer membrane 、 Kin discrimination 、 Cell biology 、 Myxobacteria 、 Expansive 、 Cell surface receptor 、 Biology 、 Lipid bilayer fusion 、 Kin recognition
摘要: Myxobacteria conduct complex social traits that requires populations to be highly related and devoid of exploiters. To enrich for clonal cells in populations, they employ kin discrimination mechanisms. One key system involves a polymorphic cell surface receptor, TraA, which recognizes self by homotypic interactions with neighboring myxobacterial cells. Recent studies revealed TraA its partner TraB are fluid outer membrane proteins coalesce into foci upon recognition kin. The formation leads transient fusion junctions the bidirectional exchange components facilitates cooperative behaviors. Additionally, expansive suites lipoprotein toxins exchanged, act as self-identity barcodes exquisitely discriminate against nonself assemble homogenous populations.