Antimutagenicity of Tochu tea (an aqueous extract of Eucommia ulmoides leaves): 1. The clastogen-suppressing effects of Tochu tea in CHO cells and mice.
作者： Takanori Nakamura , Yoshihisa Nakazawa , Shigenori Onizuka , Saori Satoh , Aki Chiba
DOI: 10.1016/S1383-5718(96)00096-4
关键词: Antimutagen 、 Botany 、 Coumaric acid 、 Micronucleus test 、 Chemistry 、 Clastogen 、 Chromosome aberration 、 Eucommia ulmoides 、 Traditional medicine 、 Protocatechuic acid 、 Micronucleus
摘要: Abstract The suppressing effect of crude extracts Tochu tea, an aqueous extract Eucommia ulmoides leaves and a popular beverage in Japan, on the induction chromosome aberrations CHO cells mice was studied. When were treated with tea after MMC treatment, frequency reduced. Out 17 components, 5 irridoids (geniposidic acid, geniposide, asperulosidic deacetyl asperuloside) 3 phenols (pyrogallol, protocatechuic p - trans -coumaric acid) found to have anticlastogenic activity. Since had α-unsaturated carbonyl group, this structure considered play important role anticlastogenicity. examined using micronucleus assay. received 1.0 ml 4% by oral gavage 6 h before intraperitoneal injection MMC, decrease micronuclei observed. This not due delay maturation micronucleated reticulocytes.
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