Managing severe pain and abuse potential: the potential impact of a new abuse-deterrent formulation oxycodone/naltrexone extended-release product.

摘要: Proper management of severe pain represents one the most challenging clinical dilemmas. Two equally important goals must be attained: humanitarian/medical goal to relieve suffering and societal/legal not contribute drug abuse problem. This is an age-old problem, prevailing emphasis placed on or other has resulted in pendulum swings that have either undertreatment current epidemic misuse abuse. In effort provide efficacious strong relievers (opioids) are more difficult by dangerous routes administration, pharmaceutical companies developing products which opioid manufactured a formulation designed tamper resistant. Such product known as abuse-deterrent (ADF). ADF deter resist making it with extracting for inhalation injection. To date, less than dozen formulations been approved US Food Drug Administration carry specific labeling, but this number will likely increase coming years. Most these extended-release formulations.