Role of astrocytes in glutamate homeostasis: implications for excitotoxicity.
作者： Arne Schousboe , Helle S. Waagepetersen
DOI: 10.1007/BF03033975
关键词: Glutamate receptor 、 Neurotoxicity 、 Excitotoxicity 、 NMDA receptor 、 Glutamate homeostasis 、 Context (language use) 、 Neurodegeneration 、 Chemistry 、 Neuroscience 、 Metabolism
摘要: Glutamate homeostasis in the brain is maintained by its well balanced release, uptake and metabolism. It appears that astrocytes play a prominent role this context since they possess very powerful battery of glutamate transporters. Thus, malfunction astrocytic transporters will lead to an excessively high extracellular concentration which may result neurodegeneration caused excitotoxic action glutamate.
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