Focal gastric mucosal blood flow in aspirin-induced ulceration.

摘要: Focal gastric mucosal blood flow was studied during aspirin injury by hydrogen gas clearance in a chambered segment model of canine corpus. Measurements were made simultaneously every 15 minutes at ulcerated and nonulcerated areas 1.5 hours before, (20 mM 150 HCl for 1 hour), 2 after exposure the mucosa to topical aspirin. There highly significant decrease (p less than 0.001) 30 aspirin, coinciding with appearance focal pallor followed subsequent hemorrhagic foci ulceration. This not recovery basal values. Blood non-ulcerated significantly but severely reduced 0.05) 90 levels. It is proposed that induces reduction varying degrees below "critical value" develop gross damage.