Cholesterol sensitivity and lipid raft targeting of Kir2.1 channels.

作者: Victor G. Romanenko , Yun Fang , Fitzroy Byfield , Alexander J. Travis , Carol A. Vandenberg

DOI: 10.1529/BIOPHYSJ.104.043273

关键词: Kir2.1Lipid raftChemistryPotassium channelEndogenyCholesterolMembrane potentialCell biologyInward-rectifier potassium ion channelTransmembrane channels

摘要: … dramatically affect the stability of rafts (Kabouridis et al.… cholesterol alter the channel activity by modifying the interactions of the channels with the protein or lipid components of lipid rafts…

参考文章(76)
Sean Munro, Lipid Rafts: Elusive or Illusive? Cell. ,vol. 115, pp. 377- 388 ,(2003) , 10.1016/S0092-8674(03)00882-1
C. Neusch, J. H. Weishaupt, M. Bähr, Kir channels in the CNS: emerging new roles and implications for neurological diseases. Cell and Tissue Research. ,vol. 311, pp. 131- 138 ,(2003) , 10.1007/S00441-002-0669-X
Scott E Forsyth, Anne Hoger, Jeff H Hoger, Molecular cloning and expression of a bovine endothelial inward rectifier potassium channel1 FEBS Letters. ,vol. 409, pp. 277- 282 ,(1997) , 10.1016/S0014-5793(97)00514-0
Péter Hajdú, Zoltán Varga, Carlo Pieri, György Panyi, Rezső Gáspár, Cholesterol modifies the gating of Kv1.3 in human T lymphocytes. Pflügers Archiv: European Journal of Physiology. ,vol. 445, pp. 674- 682 ,(2003) , 10.1007/S00424-002-0974-Y
Elena N. Makhina, Robert W. Mercer, Colin G. Nichols, Anatoli N. Lopatin, Aaron J. Kelly, Cloning and expression of a novel human brain inward rectifier potassium channel. Journal of Biological Chemistry. ,vol. 269, pp. 20468- 20474 ,(1994) , 10.1016/S0021-9258(17)32016-1
K. B. Nolop, U. S. Ryan, Enhancement of tumor necrosis factor-induced endothelial cell injury by cycloheximide. American Journal of Physiology-lung Cellular and Molecular Physiology. ,vol. 259, ,(1990) , 10.1152/AJPLUNG.1990.259.2.L123
Kai Simons, Derek Toomre, Lipid rafts and signal transduction Nature Reviews Molecular Cell Biology. ,vol. 1, pp. 31- 39 ,(2000) , 10.1038/35036052
Y. Kurachi, A. Jahangir, M. Yamada, I. Findlay, K.-I. Morishige, H. Koyama, N. Takahashi, Molecular cloning and functional expression of cDNA encoding a second class of inward rectifier potassium channels in the mouse brain. Journal of Biological Chemistry. ,vol. 269, pp. 23274- 23279 ,(1994) , 10.1016/S0021-9258(17)31649-6
Hailin Zhang, Cheng He, Xixin Yan, Tooraj Mirshahi, Diomedes E. Logothetis, Activation of inwardly rectifying K+ channels by distinct PtdIns(4,5)P2 interactions. Nature Cell Biology. ,vol. 1, pp. 183- 188 ,(1999) , 10.1038/11103
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)