Mycoplasma pulmonis and lymphoma in bioassays in rats.

摘要: Lymphomas were reported to be induced in rats bioassays of aspartame, methyl-tertiary-butyl ether (MTBE), and other chemicals conducted by a nonprofit cancer research organization. European regulatory authorities concluded that lymphomas the aspartame study caused Mycoplasma pulmonis suggested this also was case for MTBE bioassay. To assess role M. these bioassays, we reviewed tumor data and, additionally, organization's bioassay methanol. For all 3 studies, most frequently hematopoietic neoplasm lympho-immunoblastic lymphoma, affected organ lung, almost half with diagnosis, lung only organ. Lesions diagnosed as lymphoma published illustrations had pleomorphic cellular morphology appeared contain neutrophils. Information from reports sources indicated lesions typical disease...