Transforming growth factor-beta 1, activin and follistatin in patients with hepatocellular carcinoma and patients with alcoholic cirrhosis.

摘要: Background: Transforming growth factor-beta 1 (TGF- β 1) exerts an inhibitory effect on DNA synthesis in hepatocytes. Activin, through different mechanisms, also exhibits apoptotic Follistatin antagonizes the actions of activin. Methods: Patients with hepatocellular carcinoma (HCC, n = 20), patients alcoholic cirrhosis ( 12), due to other causes 5) and normal controls 19) were studied. TGF- 1, activin follistatin concentrations blood ascites measured by ELISA. Results: All three groups had significantly higher serum levels total compared those controls. In HCC, TGF level correlated negatively tumour size r =-0.644, P 0.001). The alkaline phosphatase (ALP) 0.374, 0.046). ALP 0.404, 0.026), glutamyl transpeptidase level...