Effect of thiamine pyrophosphate on ischemia-reperfusion induced oxidative damage in rat kidney.
作者： Halis Suleyman , Durdu Altuner , Nihal Cetin , Bahadir Suleyman , Zeynep Aslan
关键词: Biochemistry 、 Internal medicine 、 Rat kidney 、 Thiamine 、 Malondialdehyde 、 Chemistry 、 Ischemia 、 Dna mutation 、 Thiamine pyrophosphate 、 Oxidative damage 、 DNA 、 Endocrinology
摘要: Objectives: The biochemical effects of thiamine pyrophosphate on ischemia-reperfusion (IR) induced oxidative damage and DNA mutation in rat kidney tissue were investigated, compared to thiamine. Materials Methods: Rats divided into four groups: Renal (RIR); + RIR (TPRIR); (TRIR); sham group (SG). Results: results experiments have shown that malondialdehyde (MDA) levels after TRIR TPRIR treatment 7.2 ± 0.5 (P > 0.05) 3.3 0.3 0.05), 5.8 0.4 0.93 0.1 Conclusions: It has been prevents increase mutagenic IR damage, whereas does not this effect.
ijp-online.com参考文章(1)
Ismail Demiryilmaz, Ebru Sener, Nihal Cetin, Durdu Altuner, Fatih Akcay, Halis Suleyman, A comparative investigation of biochemical and histopathological effects of thiamine and thiamine pyrophosphate on ischemia–reperfusion induced oxidative damage in rat ovarian tissue Archives of Pharmacal Research. ,vol. 36, pp. 1133- 1139 ,(2013) , 10.1007/S12272-013-0173-8