Exploring the Protective Effect of Ascorbic Acid and Aqueous Extract of Spirulina platensis on Methotrexate-Induced Lipid Peroxidation

作者: Kunal Roy , Supratim Ray , Chandana Sengupta

DOI:

关键词: In vitroMethotrexateFood scienceNitric oxideMalondialdehydeBiochemistrySpirulina (dietary supplement)GlutathioneChemistryLipid peroxidationAscorbic acid

摘要: This study was designed to explore the protective effects of ascorbic acid and water extract Spirulina platensis (blue green algae) on methotrexate-induced lipid peroxidation using goat liver as source. in vitro evaluation done by measuring malondialdehyde, 4-hydroxy-2-nonenal, reduced glutathione nitric oxide content tissue homogenates. The reveals induction capacity methotrexate, anti-peroxidative potential aqueous S. peroxidation.

参考文章(48)
William F. Hodnick, Sami Ahmad, Ronald S. Pardini, Induction of oxidative stress by redox active flavonoids. Advances in Experimental Medicine and Biology. ,vol. 439, pp. 131- 150 ,(1998) , 10.1007/978-1-4615-5335-9_10
Irwin M. Arias, William B. Jakoby, Glutathione, metabolism and function Raven Press. ,(1976)
Barry. Halliwell, John M. C. Gutteridge, Antioxidants in Nutrition, Health, and Disease ,(1995)
Tal Offer, Angelo Russo, Amram Samuni, The pro-oxidative activity of SOD and nitroxide SOD mimics The FASEB Journal. ,vol. 14, pp. 1215- 1223 ,(2000) , 10.1096/FASEBJ.14.9.1215
Carl Nathan, Nitric oxide as a secretory product of mammalian cells. The FASEB Journal. ,vol. 6, pp. 3051- 3064 ,(1992) , 10.1096/FASEBJ.6.12.1381691
Barry Halliwell, DRUG ANTIOXIDANT EFFECTS-A BASIS FOR DRUG SELECTION Drugs. ,vol. 42, pp. 569- 605 ,(1991) , 10.2165/00003495-199142040-00003
Angelo Benedetti, Mario Comporti, Hermann Esterbauer, Identification of 4-hydroxynonenal as a cytotoxic product originating from the peroxidation of liver microsomal lipids☆ Biochimica et Biophysica Acta. ,vol. 620, pp. 281- 296 ,(1980) , 10.1016/0005-2760(80)90209-X
Hiroshi Ohkawa, Nobuko Ohishi, Kunio Yagi, Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction Analytical Biochemistry. ,vol. 95, pp. 351- 358 ,(1979) , 10.1016/0003-2697(79)90738-3
K. Köse, P. Dosgan, Ç. Özesmi, Contraceptive steroids increase erythrocyte lipid peroxidation in female rats Contraception. ,vol. 47, pp. 421- 425 ,(1993) , 10.1016/0010-7824(93)90039-A
Homero Rubbo, Sampath Parthasarathy, Stephen Barnes, Marion Kirk, B. Kalyanaraman, Bruce A. Freeman, Nitric oxide inhibition of lipoxygenase-dependent liposome and low-density lipoprotein oxidation: termination of radical chain propagation reactions and formation of nitrogen-containing oxidized lipid derivatives. Archives of Biochemistry and Biophysics. ,vol. 324, pp. 15- 25 ,(1995) , 10.1006/ABBI.1995.9935