Analyzing 395,793 samples shows significant association between rs999737 polymorphism and breast cancer

作者: Haiying Dong , Zhiying Gao , Chengchong Li , Junping Wang , Ming Jin

DOI: 10.1007/S13277-014-1805-4

关键词: AlleleBioinformaticsBreast cancerGenetic associationOdds ratioPolymorphism (computer science)OncologyGenetic heterogeneityInternal medicineConfidence intervalGenome-wide association studyBiologyGeneral Medicine

摘要: Large-scale genome-wide association studies (GWAS) have been conducted and reported the between rs999737 polymorphism at 14q24.1 (RAD51L1) breast cancer risk. Following investigated in European Asian populations. However, some of these weak no significant association. Here, we reevaluated this using large-scale samples from previous 11 (n = 395,793; 162,261 cases 233,532 controls) PubMed database. We evaluated genetic heterogeneity among selected studies. The pooled odds ratio (OR) is calculated by fixed effect model. All statistical tests for meta-analysis were computed R package. did not identify included allele model (P = 0.1314 I 2 = 33.4 %). observed (P = 2.47E − 35, OR = 0.92, 95 % confidence interval (CI) 0.91–0.93). Our analysis further supports findings that contributes to susceptibility. believe our finding will be very useful future cancer.

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