Tumor-Associated Macrophages as Potential Prognostic Biomarkers of Invasive Breast Cancer.
作者： Hasong Jeong , Ilseon Hwang , Sun Hee Kang , Hyeong Chan Shin , Sun Young Kwon
关键词: Estrogen receptor 、 Cancer research 、 CD163 、 Progesterone receptor 、 CD11c 、 Immunohistochemistry 、 Tissue microarray 、 Tumor progression 、 CD68 、 Medicine
摘要: Purpose Tumor-associated macrophages (TAMs) are activated associated with tumor progression in various cancers. TAMs can polarize M1 or M2 type. has a pro-inflammatory function and kills pathogens. Conversely, shows immunosuppressive action promotes growth. There markers of TAMs. CD11c is considered as specific marker M1. CD163 an optimal for M2. CD68 known pan-macrophage marker. We evaluated the relationship between clinicopathological parameters immunohistochemical expressions CD11c, CD163, invasive breast cancer (IBC), prognostic value macrophage localization within stroma (TS) nest (TN). Methods Immunohistochemistry CD68, was analyzed on tissue microarrays 367 IBCs. The number CD68+, CD11c+, CD163+ TN vs. TS counted by 2 pathologists. correlations degree (CD68+, CD163+) infiltration were analyzed. also assessed impact disease free survival (DFS) overall (OS). Results High numbers higher histologic grade, Ki-67 proliferating index, estrogen receptor negativity, progesterone negativity. (CD11c+ larger size. Furthermore, independent reduced OS DFS. CD11c+ Conclusion TAMs, including type, IBC. They act significant unfavorable favorable factor. In addition to simply analyzing TAM infiltration, it important analyze location
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