Gut Microbiota in Metabolic Syndrome
作者： Fredrik Bäckhed
DOI: 10.1007/978-3-319-01008-3_9
关键词: Biology 、 Metabolic syndrome 、 Gut flora 、 Gut–brain axis 、 Obesity 、 Immunology 、 Human gut 、 Microbial Genes
摘要: The human gut is colonized by trillions of bacteria that complement our own genes with 150-fold more microbial genes. Acting at the intersection between diet and host biology microbiota can be considered a metabolic organ affects physiology. Here we explore evidence supports hypothesis there dynamic interrelationship plays an important role in nutrition as well modulating energy balance. Furthermore, altered obesity germ-free mice have reduced adiposity are protected against diet-induced obesity. Accordingly, may environmental factor contributes to diseases.
springer.com
sci-hub.se 参考文章(58)
R. Caesar, F. Fåk, F. Bäckhed, Effects of gut microbiota on obesity and atherosclerosis via modulation of inflammation and lipid metabolism. Journal of Internal Medicine. ,vol. 268, pp. 320- 328 ,(2010) , 10.1111/J.1365-2796.2010.02270.X
Jeffrey I. Gordon, Jian Xu, Inaugural Article by a Recently Elected Academy Member Proceedings of the National Academy of Sciences of the United States of America. ,vol. 100, pp. 10452- ,(2003) , 10.1073/PNAS.1734063100
B. S. Wostmann, Intestinal Bile Acids and Cholesterol Absorption in the Germfree Rat The Journal of Nutrition. ,vol. 103, pp. 982- 990 ,(1973) , 10.1093/JN/103.7.982
Christopher S. Reigstad, Gunnel Östergren Lundén, Jenny Felin, Fredrik Bäckhed, Regulation of Serum Amyloid A3 (SAA3) in Mouse Colonic Epithelium and Adipose Tissue by the Intestinal Microbiota PLoS ONE. ,vol. 4, pp. e5842- ,(2009) , 10.1371/JOURNAL.PONE.0005842
Barbara B. Kahn, Thierry Alquier, David Carling, D. Grahame Hardie, AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism Cell Metabolism. ,vol. 1, pp. 15- 25 ,(2005) , 10.1016/J.CMET.2004.12.003
R. E. Ley, F. Backhed, P. Turnbaugh, C. A. Lozupone, R. D. Knight, J. I. Gordon, Obesity Alters Gut Microbial Ecology Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 11070- 11075 ,(2005) , 10.1073/PNAS.0504978102
Sandrine P Claus, Tsz M Tsang, Yulan Wang, Olivier Cloarec, Eleni Skordi, François‐Pierre Martin, Serge Rezzi, Alastair Ross, Sunil Kochhar, Elaine Holmes, Jeremy K Nicholson, Systemic multicompartmental effects of the gut microbiome on mouse metabolic phenotypes. Molecular Systems Biology. ,vol. 4, pp. 219- 219 ,(2008) , 10.1038/MSB.2008.56
E. K. Costello, C. L. Lauber, M. Hamady, N. Fierer, J. I. Gordon, R. Knight, Bacterial Community Variation in Human Body Habitats Across Space and Time Science. ,vol. 326, pp. 1694- 1697 ,(2009) , 10.1126/SCIENCE.1177486
Christine K. Fleissner, Nora Huebel, Mohamed Mostafa Abd El-Bary, Gunnar Loh, Susanne Klaus, Michael Blaut, Absence of intestinal microbiota does not protect mice from diet-induced obesity. British Journal of Nutrition. ,vol. 104, pp. 919- 929 ,(2010) , 10.1017/S0007114510001303
Andrew L. Kau, Philip P. Ahern, Nicholas W. Griffin, Andrew L. Goodman, Jeffrey I. Gordon, Human nutrition, the gut microbiome and the immune system. Nature. ,vol. 474, pp. 327- 336 ,(2011) , 10.1038/NATURE10213