Serial Observations after High Dose Talc Slurry in the Rabbit Model for Pleurodesis

摘要: The mechanisms leading to a pleurodesis after the intrapleural injection of sclerosing agent are not completely understood. purpose present study was make serial observations over 28 days on pleural fluid findings and gross microscopic changes in pleura talc slurry administered intrapleurally at high dose. Sixty-six rabbits received 400 mg/kg slurry. Ten 12 were sacrificed 1, 2, 4, 7, 14, injection. At sacrifice measured analyzed, surfaces studied grossly microscopically. resulted an acute exudative effusion that persisted for 4 days. There progressive increase fibrosis Talc time all animals. there clinically significant rabbits; observed before this time. From we conclude leads is day but 14. It appears production requires higher doses without chest tube than humans with tube.