Recent studies of aldose reductase enzyme inhibition for diabetic complications.

摘要: Aldose reductase [ALR2; EC 1.1.1.21], a key enzyme of polyol pathway, catalyzes NADPH-dependent reduction glucose to sorbitol (Sorbitol pathway), and an excessive accumulation intracellular found in various tissues diabetic animals cells cultured under high conditions has been proposed be important factor for the pathogenesis complications. The only strategy shown consistently beneficial treatment complications is meticulous control blood glucose. However, aldose (AR) inhibition becoming one therapeutic strategies that have prevent or ameliorate long-term Therefore, AR inhibitors (AR1s) hold promise reducing metabolic nerve injury, but further study needed. On other hand, there strong evidence show diabetes associated with increased oxidative stress. source this stress remains unclear. This relationship between free radical production was also investigation. studies suggest hydroxyl indirectly inhibited by ARIs resulting from decreasing levels formation related early stages complications, possibly via Fenton reaction involving H 2 O produced activated pathway. it may accelerate damage cell membranes accumulation. search specific still become major pharmaceutic challenge, though number so far assessed