Vitamin‐B12 (Cobalamin) and Folate Deficiency

摘要: Although deficiencies of vitamin B12 (aka, cobalamin) and folate can present similarly with megaloblastic anemia, alone causes neuropsychiatric disorders. Therefore, replacement the correct is essential to ensure a prompt cure. In developing countries, both vitamins commonly arise from dietary insufficiency. But in developed malabsorption more common, especially because food fortification folate. The cause deficiency often found past 6 months, whereas due autoimmune pernicious anemia or food-B12 presents insidiously. Upon clinical suspicion deficiency, conventional tests for serum are appropriate, specialized metabolite needed when test results equivocal. However, setting hemolysis be normal despite tissue deficiency. There several established indications prophylaxis supplementation appropriate setting.